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Recurrent FOSL1 rearrangements in desmoplastic fibroblastoma

25 Nov 2022

Abstract excerpt

The FOS gene family has been implicated in tumourigenesis across several tumour types, particularly mesenchymal tumours. The rare fibrous tumour desmoplastic fibroblastoma is characterised by overexpression of FOSL1. However, previous studies using cytogenetic and molecular techniques did not identify an underlying somatic change involving the FOSL1 gene to explain this finding. Prompted by an unusual index case,...

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PMID: 36426824
DOI: 10.1002/path.6038

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