Article
Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice.
The EMBO journal - 4 Jan 2023
Hu Qianying, Zhang Na, Sui Tingting, Li Guanlin, Wang Zhiyao, Liu Mingyue, Zhu Xiaojuan, Huang Baiqu, Lu Jun, Li Zhanjun, Zhang Yu
Abstract excerpt
Hutchinson-Gilford progeria syndrome (HGPS) is a lethal premature aging disorder without an effective therapeutic regimen. Because of their targetability and influence on gene expression, microRNAs (miRNAs) are attractive therapeutic tools to treat diseases. Here we identified that hsa-miR-59 (miR-59) was markedly upregulated in HGPS patient cells and in multiple tissues of an HGPS mouse model (LmnaG609G/G609G ),...
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