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Article

Anti-cancer effect of targeting fibroblast activation protein alpha in glioblastoma through remodeling macrophage phenotype and suppressing tumor progression.

CNS neuroscience & therapeutics - 1 Mar 2023

Miao Yazhou, Deng Yuxuan, Liu Jinqiu, Wang Jing, Hu Boyi, Hao Shuyu, Wang Herui, Zhang Zhe, Jin Zeping, Zhang Yang, Li Chunzhao, Zhang Peng, Wan Hong, Zhang Shaodong, Feng Jie, Ji Nan

Abstract excerpt

INTRODUCTION: Glioblastoma (GBM) is the most malignant form of glioma and has a poor median survival time. Fibroblast activation protein alpha (FAP) is a dual-specificity serine protease that is strongly associated with the development and progression of human carcinomas. However, relatively little is known about the function of FAP and its potential as a therapeutic target in GBMs. AIMS: In this study, we aimed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36382346
DOI: 10.1111/cns.14024
PMCID: PMC9928553

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