A high number of co-occurring genomic alterations detected by NGS is associated with worse clinical outcomes in advanced EGFR-mutant lung adenocarcinoma: Data from LATAM population.

doi:10.1016/j.lungcan.2022.11.002

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Article

A high number of co-occurring genomic alterations detected by NGS is associated with worse clinical outcomes in advanced EGFR-mutant lung adenocarcinoma: Data from LATAM population.

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2022

Heredia David, Mas Luis, Cardona Andres F, Oyervides Víctor, Motta Guerrero Rodrigo, Galvez-Nino Marco, Lara-Mejía Luis, Aliaga-Macha Carlos, Carracedo Carlos, Varela-Santoyo Edgar, Ramos-Ramírez Maritza, Davila-Dupont David, Martínez Juan, Cruz-Rico Graciela, Remon Jordi, Arrieta Oscar

Abstract excerpt

BACKGROUND: Co-occurring genomic alterations identified downstream main oncogenic drivers have become more evident since the introduction of next-generation sequencing (NGS) analyses at diagnosis and progression. Emerging evidence has stated that co-occurring genomic alterations at diagnosis might represent de novo and primary resistance mechanisms to tyrosine kinase inhibitors (TKIs) in advanced EGFR-mutant...

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PMID: 36379126
DOI: 10.1016/j.lungcan.2022.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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