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Article

Effects of Co-occurring Genomic Alterations on Outcomes in Patients with KRAS-Mutant Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2018

Arbour Kathryn C, Jordan Emmett, Kim Hyunjae Ryan, Dienstag Jordan, Yu Helena A, Sanchez-Vega Francisco, Lito Piro, Berger Michael, Solit David B, Hellmann Matthew, Kris Mark G, Rudin Charles M, Ni Ai, Arcila Maria, Ladanyi Marc, Riely Gregory J

Abstract excerpt

Purpose:KRAS mutations occur in approximately 25% of patients with non-small cell lung cancer (NSCLC). Despite the uniform presence of KRAS mutations, patients with KRAS-mutant NSCLC can have a heterogeneous clinical course. As the pattern of co-occurring mutations may describe different biological subsets of patients with KRAS-mutant lung adenocarcinoma, we explored the effects of co-occurring mutations on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29089357
DOI: 10.1158/1078-0432.CCR-17-1841
PMCID: PMC5771996

Genes

KRAS
KEAP1
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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