Article
Association of xenobiotic-metabolizing genes polymorphisms with cervical cancer risk in the Tunisian population.
Molecular biology reports - 1 Feb 2023
Helaoui Ahlem, Sfar Sana, Boudhiba Najet, Dehghanian Fariba, Dehbashi Moein, Bouchahda Haifa, Hojati Zohreh, Kenani Abderraouf
Abstract excerpt
BACKGROUND: Host genetic characteristics and environmental factors interactions may play a crucial role in cervical carcinogenesis. We investigated the impact of functional genetic variants of four xenobiotic-metabolizing genes (AhR, CYP1A1, GSTM1, and GSTT1) on cervical cancer development in Tunisian women. METHODS: The AhR gene polymorphism was analyzed using the tetra-primer ARMS-PCR, whereas the CYP1A1...
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