Article
Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2.
Molecules (Basel, Switzerland) - 1 Nov 2022
Fu Jiewen, Liu Shuguang, Tan Qi, Liu Zhiying, Qian Jie, Li Ting, Du Jiaman, Song Binghui, Li Dabing, Zhang Lianmei, He Jiayue, Guo Kan, Zhou Baixu, Chen Hanchun, Fu Shangyi, Liu Xiaoyan, Cheng Jingliang, He Tao, Fu Junjiang
Abstract excerpt
As a cellular protease, transmembrane serine protease 2 (TMPRSS2) plays roles in various physiological and pathological processes, including cancer and viral entry, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we conducted expression, mutation, and prognostic analyses for the TMPRSS2 gene in pan-cancers as well as in COVID-19-infected lung tissues. The results indicate that...
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