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The Molecular Interplay between Human Oncoviruses and Telomerase in Cancer Development

26 Oct 2022

Abstract excerpt

Human oncoviruses are able to subvert telomerase function in cancer cells through multiple strategies. The activity of the catalytic subunit of telomerase (TERT) is universally enhanced in virus-related cancers. Viral oncoproteins, such as high-risk human papillomavirus (HPV) E6, Epstein-Barr virus (EBV) LMP1, Kaposi's sarcoma-associated herpesvirus (HHV-8) LANA, hepatitis B virus (HBV) HBVx, hepatitis C virus...

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PMID: 36358677
DOI: 10.3390/cancers14215257

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