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The role of telomerase and viruses interaction in cancer development, and telomerase-dependent therapeutic approaches

1 Jan 2021

Abstract excerpt

Human telomerase reverse transcriptase (hTERT) is an enzyme that is critically involved in elongating and maintaining telomeres length to control cell life span and replicative potential. Telomerase activity is continuously expressed in human germ-line cells and most cancer cells, whereas it is suppressed in most somatic cells. In normal cells, by reducing telomerase activity and progressively shortening the...

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PMID: 33530025
DOI: 10.1016/j.ctarc.2021.100323

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