Inoculum Concentration Influences Pseudomonas aeruginosa Phenotype and Biofilm Architecture.

Abstract excerpt

In infections, bacterial cells are often found as relatively small multicellular aggregates characterized by a heterogeneous distribution of phenotype, genotype, and growth rates depending on their surrounding microenvironment. Many laboratory models fail to mimic these characteristics, and experiments are often initiated from planktonic bacteria given optimal conditions for rapid growth without concerns about...

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