Article
Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm.
PloS one - 1 Jan 2011
Alhede Morten, Kragh Kasper Nørskov, Qvortrup Klaus, Allesen-Holm Marie, van Gennip Maria, Christensen Louise D, Jensen Peter Østrup, Nielsen Anne K, Parsek Matt, Wozniak Dan, Molin Søren, Tolker-Nielsen Tim, Høiby Niels, Givskov Michael, Bjarnsholt Thomas
Abstract excerpt
For a chronic infection to be established, bacteria must be able to cope with hostile conditions such as low iron levels, oxidative stress, and clearance by the host defense, as well as antibiotic treatment. It is generally accepted that biofilm formation facilitates tolerance to these adverse conditions. However, microscopic investigations of samples isolated from sites of chronic infections seem to suggest that...
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