Article
A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle.
BMC genomics - 27 May 2010
Meyers Stacey N, McDaneld Tara G, Swist Shannon L, Marron Brandy M, Steffen David J, O'Toole Donal, O'Connell Jeffrey R, Beever Jonathan E, Sonstegard Tad S, Smith Timothy P L
Abstract excerpt
BACKGROUND: Osteopetrosis is a skeletal disorder of humans and animals characterized by the formation of overly dense bones, resulting from a deficiency in the number and/or function of bone-resorbing osteoclast cells. In cattle, osteopetrosis can either be induced during gestation by viral infection of the dam, or inherited as a recessive defect. Genetically affected calves are typically aborted late in...
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