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Knockdown and mutation of Pou4f3 gene mutation promotes pyroptosis of cochleae in cisplatin-induced deafness mice by NLRP3/caspase-3/GSDME pathway.

Toxicology - 1 Dec 2022

Yu Rong, Wang Kai, Luo Wugen, Jiang Hongqun

Abstract excerpt

OBJECTIVE: To investigate the effect and mechanism of Pou4f3 gene mutation on pyroptosis in cochleae of cisplatin-induced deafness mice. METHODS: Mice were intraperitoneally injected with cisplatin to construct an animal model of deafness, and sh-Pou4f3 and mutant vector were injected to alter gene expression. TUNEL staining was used to assess the apoptosis level of cochlear hair cells, ELISA was used to detect...

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PMID: 36341876
DOI: 10.1016/j.tox.2022.153368

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