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Aortic Aneurysm Risk and the Somatic JAK2 V617F Mutation: Insights From a Multicenter, Population-Based Cardiovascular Screening Study

4 Jun 2025

Abstract excerpt

BACKGROUND: The somatic JAK2 V617F sequence variation, a key driver of myeloproliferative neoplasms, has been associated with increased risk of aortic aneurysms. This study aimed to explore associations between the JAK2 V617F variant allele frequency (VAF) and ascending, descending, and abdominal aortic aneurysms. METHODS: In the DANCAVAS I and II trials (Danish Cardiovascular Screening), 15 000 individuals...

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PMID: 40464064
DOI: 10.1161/circulationaha.125.074002

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