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Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing

3 Nov 2022

Abstract excerpt

Multiple myeloma is a plasma cell neoplasm characterized by clonal immunoglobulin V(D)J signatures and oncogenic immunoglobulin gene translocations. Additional subclonal genomic changes are acquired with myeloma progression and therapeutic selection. PCR-based methods to detect V(D)J rearrangements can have biases introduced by highly multiplexed reactions and primers undermined by somatic hypermutation, and are...

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PMID: 36328595
DOI: 10.26508/lsa.202201543

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