Article
Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.
Nature - 1 Nov 2022
Wang Teh-Wei, Johmura Yoshikazu, Suzuki Narumi, Omori Satotaka, Migita Toshiro, Yamaguchi Kiyoshi, Hatakeyama Seira, Yamazaki Satoshi, Shimizu Eigo, Imoto Seiya, Furukawa Yoichi, Yoshimura Akihiko, Nakanishi Makoto
Abstract excerpt
The accumulation of senescent cells is a major cause of age-related inflammation and predisposes to a variety of age-related diseases1. However, little is known about the molecular basis underlying this accumulation and its potential as a target to ameliorate the ageing process. Here we show that senescent cells heterogeneously express the immune checkpoint protein programmed death-ligand 1 (PD-L1) and that...
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