Article
Competitive evolved sub-clonal BCR::ABL1 and novel MSI2::PC fusion genes in myelodysplastic syndrome with isolated del(5q).
Hematological oncology - 1 Feb 2023
Zhang Yanqing, Liu Yang, Wang Tong, Wang Hui, Chen Xue, Cao Panxiang, Ma Xiaoli, Liu Mingyue, Xu Ping, Bi Hailiang, Pan Jiaqi, Jiang Yongfang, Li Xiaoyun, Wang Wei, Liu Hongxing
Abstract excerpt
Myelodysplastic syndrome (MDS) represents a group of neoplasms with extensive heterogeneity. Recurrent mutations in dozens of driver genes have been identified in over 90% of MDS cases, although fusion genes are rarely seen. We first report the competitive evolved sub-clonal breakpoint cluster region (BCR)::ABL1 and novel MSI2::PC fusion gene in MDS with del(5q) in initial diagnosis that underwent dismal...
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