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Intrahost SARS-CoV-2 k-mer Identification Method (iSKIM) for Rapid Detection of Mutations of Concern Reveals Emergence of Global Mutation Patterns.

Viruses - 27 Sept 2022

Thommana Ashley, Shakya Migun, Gandhi Jaykumar, Fung Christian K, Chain Patrick S G, Maljkovic Berry Irina, Conte Matthew A

Abstract excerpt

Despite unprecedented global sequencing and surveillance of SARS-CoV-2, timely identification of the emergence and spread of novel variants of concern (VoCs) remains a challenge. Several million raw genome sequencing runs are now publicly available. We sought to survey these datasets for intrahost variation to study emerging mutations of concern. We developed iSKIM ("intrahost SARS-CoV-2 k-mer identification...

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PMID: 36298683
DOI: 10.3390/v14102128
PMCID: PMC9609618

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