Article
cd1 Mutation in Drosophila Affects Phenoxazinone Synthase Catalytic Site and Impairs Long-Term Memory.
International journal of molecular sciences - 15 Oct 2022
Zhuravlev Aleksandr V, Ivanova Polina N, Makaveeva Ksenia A, Zakharov Gennadii A, Nikitina Ekaterina A, Savvateeva-Popova Elena V
Abstract excerpt
Being involved in development of Huntington's, Parkinson's and Alzheimer's diseases, kynurenine pathway (KP) of tryptophan metabolism plays a significant role in modulation of neuropathology. Accumulation of a prooxidant 3-hydroxykynurenine (3-HOK) leads to oxidative stress and neuronal cell apoptosis. Drosophila mutant cardinal (cd1) with 3-HOK excess shows age-dependent neurodegeneration and short-term memory...
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