Article
Longitudinal in Utero Analysis of Engrailed-1 Knockout Mouse Embryonic Phenotypes Using High-Frequency Ultrasound.
Ultrasound in medicine & biology - 1 Jan 2023
Aristizábal Orlando, Qiu Ziming, Gallego Estefania, Aristizábal Matias, Mamou Jonathan, Wang Yao, Ketterling Jeffrey A, Turnbull Daniel H
Abstract excerpt
Large-scale international efforts to generate and analyze loss-of-function mutations in each of the approximately 20,000 protein-encoding gene mutations are ongoing using the "knockout" mouse as a model organism. Because one-third of gene knockouts are expected to result in embryonic lethality, it is important to develop non-invasive in utero imaging methods to detect and monitor mutant phenotypes in mouse...
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