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Article

The role of NPM1 alternative splicing in patients with chronic lymphocytic leukemia.

PloS one - 1 Jan 2022

Szelest Monika, Masternak Marta, Zając Małgorzata, Chojnacki Michał, Skórka Katarzyna, Zaleska Joanna, Karczmarczyk Agnieszka, Stasiak Grażyna, Wawrzyniak Ewa, Kotkowska Aleksandra, Siemieniuk-Ryś Monika, Purkot Joanna, Subocz Edyta, Cichocka Edyta, Tomczak Waldemar, Zawirska Daria, Giannopoulos Krzysztof

Abstract excerpt

OBJECTIVES: Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disease with heterogeneous clinical course. Recent studies revealed a link between NOTCH1 mutation and the overexpression of MYC and MYC-related genes involved in ribosome biogenesis and protein biosynthesis, such as nucleophosmin-1 (NPM1), in CLL cells. In the present study, we aim to evaluate the impact of the NOTCH1 mutation on the MYC and...

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Identifiers

PMID: 36282861
DOI: 10.1371/journal.pone.0276674
PMCID: PMC9595542

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