Article

Identification of a distinct AREG+ cell population that promotes the progression, recurrence, and metastasis of endometrioid endometrial cancer at single-cell resolution

2026-02-27

Abstract excerpt

<title>Abstract</title> <p> Endometrial cancer (EC) is the second most common malignant tumor of the female reproductive system worldwide. Endometrioid endometrial cancer (EEC) constitutes the most prevalent subtype, representing approximately 75% of all EC cases. Most patients diagnosed with EEC present at an early stage and generally exhibit a favorable prognosis. However, a small subset of low-grade, early-st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d73b6b72-e7f4-55bf-9a36-9996b08635ac
DOI: 10.21203/rs.3.rs-8692432/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a distinct AREG+ cell population that promotes the progression, recurrence, and metastasis of endometrioid endometrial cancer at single-cell resolutionDOI 10.21203/rs.3.rs-8692432/v1Read

Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinomaSemantic proximity Read

Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscapeSemantic proximity Read

Comprehensive Review of Endometrial Cancer: New Molecular and FIGO Classification and Recent Treatment ChangesSemantic proximity Read

Single-cell transcriptome profiles the heterogeneity of tumor cells and microenvironments for different pathological endometrial cancer and identifies specific sensitive drugsSemantic proximity Read

Single-cell RNA-seq reveals FGF12 as a prognostic biomarker in low-grade endometrial stromal sarcomaSemantic proximity Read

SPARC was overexpressed in human endometrial cancer stem-like cells and promoted migration activitySemantic proximity Read

A multi-omic single-cell landscape of human gynecologic malignanciesSemantic proximity Read

High-grade endometrial carcinomas: Morphologic spectrum and molecular classification.Semantic proximity Read

Clinical characteristics and prognostic characterization of endometrial carcinoma: a comparative analysis of molecular typing protocols.Semantic proximity Read

Single-cell Transcriptomic Analysis of Eutopic Endometrium and Ectopic Lesions of AdenomyosisSemantic proximity Read

The Histomorphology to Molecular Transition: Exploring the Genomic Landscape of Poorly Differentiated Epithelial Endometrial CancersSemantic proximity Read

Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatmentSemantic proximity Read