Article
Toll-like receptor and matrix metalloproteinase single-nucleotide polymorphisms, haplotypes, and polygenic risk score differentiated between tuberculosis disease and infection.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Dec 2022
Lee Meng-Rui, Chen Yen-Lin, Wu Chang-Wei, Chen Lun-Che, Chang Lih-Yu, Chen Jung-Yueh, Huang Yu-Tsung, Wang Jann-Yuan, Shih Jin-Yuan, Yu Chong-Jen
Abstract excerpt
OBJECTIVES: The association of toll-like receptors (TLRs) and matrix metalloproteinases (MMPs) single-nucleotide polymorphisms (SNPs) among latent tuberculosis (TB) infection and active TB remained less studied. METHODS: We recruited participants with TB disease (active TB) (n = 400) and TB infection (latent TB infection) (n = 203) in this study. We genotyped SNPs in TLR1, TLR2, TLR4, MMP1, MMP8, MMP9, MMP12, and...
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