Article
A high-throughput skim-sequencing approach for genotyping, dosage estimation and identifying translocations.
Scientific reports - 20 Oct 2022
Adhikari Laxman, Shrestha Sandesh, Wu Shuangye, Crain Jared, Gao Liangliang, Evers Byron, Wilson Duane, Ju Yoonha, Koo Dal-Hoe, Hucl Pierre, Pozniak Curtis, Walkowiak Sean, Wang Xiaoyun, Wu Jing, Glaubitz Jeffrey C, DeHaan Lee, Friebe Bernd, Poland Jesse
Abstract excerpt
The development of next-generation sequencing (NGS) enabled a shift from array-based genotyping to directly sequencing genomic libraries for high-throughput genotyping. Even though whole-genome sequencing was initially too costly for routine analysis in large populations such as breeding or genetic studies, continued advancements in genome sequencing and bioinformatics have provided the opportunity to capitalize...
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