Article
IgE type multiple myeloma exhibits hypermutated phenotype and tumor reactive T cells.
Journal for immunotherapy of cancer - 1 Oct 2022
Kehl Niklas, Kilian Michael, Michel Julius, Wagner Tim R, Uhrig Sebastian, Brobeil Alexander, Sester Lilli-Sophie, Blobner Sven, Steiger Simon, Hundemer Michael, Weinhold Niels, Rippe Karsten, Fröhling Stefan, Eichmüller Stefan B, Bunse Lukas, Müller-Tidow Carsten, Goldschmidt Hartmut, Platten Michael, Raab Marc-Steffen, Friedrich Mirco J
Abstract excerpt
Multiple myeloma (MM) is a hematological malignancy originating from malignant and clonally expanding plasma cells. MM can be molecularly stratified, and its clonal evolution deciphered based on the Ig heavy and light chains of the respective malignant plasma cell clone. Of all MM subtypes, IgE type MM accounts for only <0.1% of cases and is associated with an aggressive clinical course and consequentially...
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