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Article

A Novel INS Mutation in the C-Peptide Region Causing Hyperproinsulinemic Maturity Onset Diabetes of Youth Type 10.

Laboratory medicine - 2 May 2023

Schlegel Amnon, Petersen Whitney C, Holbrook Alexandra A, Iverson Leslie K, Graham Timothy E

Abstract excerpt

Monogenetic diabetes mellitus (DM) describes a collection of single-gene diseases marked by hyperglycemia presenting in childhood or adulthood and the absence of immunological markers of type 1 DM. Mutations in the human insulin gene INS give rise to two separate clinical syndromes: permanent neonatal DM, type 4 (PNDM4), and maturity-onset diabetes of youth, type 10 (MODY10); the former presents shortly after...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36242597
DOI: 10.1093/labmed/lmac115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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A Novel INS Mutation in the C-Peptide Region Causing Hyperproinsulinemic Maturity Onset Diabetes of Youth Type 10.PMID 36242597Read ↗

A novel INS mutation in a family with maturity-onset diabetes of the young: Variable insulin secretion and putative mechanismsSemantic proximity Read ↗

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Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.Semantic proximity Read ↗

Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).Semantic proximity Read ↗

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Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism.Semantic proximity Read ↗

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