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Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

Diabetes - 1 Apr 2008

Molven Anders, Ringdal Monika, Nordbø Anita M, Raeder Helge, Støy Julie, Lipkind Gregory M, Steiner Donald F, Philipson Louis H, Bergmann Ines, Aarskog Dagfinn, Undlien Dag E, Joner Geir, Søvik Oddmund, Bell Graeme I, Njølstad Pål R

Abstract excerpt

OBJECTIVE: Mutations in the insulin (INS) gene can cause neonatal diabetes. We hypothesized that mutations in INS could also cause maturity-onset diabetes of the young (MODY) and autoantibody-negative type 1 diabetes. RESEARCH DESIGN AND METHODS: We screened INS in 62 probands with MODY, 30 probands with suspected MODY, and 223 subjects from the Norwegian Childhood Diabetes Registry selected on the basis of...

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Identifiers

PMID: 18192540
DOI: 10.2337/db07-1467

Genes

INS

Variants

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