NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

doi:10.1182/blood.2022017003

Article

NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol

14 Oct 2022

Abstract excerpt

We compared minimal/measurable residual disease (MRD) levels evaluated by routinely used real-time quantitative polymerase chain reaction (qPCR) patient-specific assays and by next-generation sequencing (NGS) approach in 780 immunoglobulin (IG) and T-cell receptor (TR) markers in 432 children with B-cell precursor acute lymphoblastic leukemia treated on the AIEOP-BFM ALL 2009 protocol. Our aim was to compare the...

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