Article
Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening.
International journal of molecular sciences - 29 Sept 2022
Vaccarin Christian, Gabbia Daniela, Franceschinis Erica, De Martin Sara, Roverso Marco, Bogialli Sara, Sacchetti Gianni, Tupini Chiara, Lampronti Ilaria, Gambari Roberto, Cabrini Giulio, Dechecchi Maria Cristina, Tamanini Anna, Marzaro Giovanni, Chilin Adriana
Abstract excerpt
A small library of new angelicin derivatives was designed and synthesized with the aim of bypassing the side effects of trimethylangelicin (TMA), a promising agent for the treatment of cystic fibrosis. To prevent photoreactions with DNA, hindered substituents were inserted at the 4 and/or 6 positions. Unlike the parent TMA, none of the new derivatives exhibited significant cytotoxicity or mutagenic effects. Among...
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