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Article

1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants.

European journal of medicinal chemistry - 1 Jan 2021

Son Jung-Ho, Phuan Puay-Wah, Zhu Jie S, Lipman Elena, Cheung Amy, Tsui Ka Yi, Tantillo Dean J, Verkman Alan S, Haggie Peter M, Kurth Mark J

Abstract excerpt

We previously identified a spiro [piperidine-4,1-pyrido [3,4-b]indole] class of co-potentiators that function in synergy with existing CFTR potentiators such as VX-770 or GLGP1837 to restore channel activity of a defined subset of minimal function cystic fibrosis transmembrane conductance regulator (CFTR) mutants. Here, structure-activity studies were conducted to improve their potency over the previously...

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Identifiers

PMID: 33092904
DOI: 10.1016/j.ejmech.2020.112888
PMCID: PMC7744356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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