Proteomic signature for detection of high-grade ovarian cancer in germline BRCA mutation carriers.

doi:10.1002/ijc.34318

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Proteomic signature for detection of high-grade ovarian cancer in germline BRCA mutation carriers.

International journal of cancer - 15 Feb 2023

Bahar-Shany Keren, Barnabas Georgina D, Deutsch Lisa, Deutsch Netanel, Glick-Saar Efrat, Dominissini Dan, Sapoznik Stav, Helpman Limor, Perri Tamar, Blecher Anna, Katz Guy, Yagel Itai, Rosenblatt Orgad, Shai Daniel, Brandt Benny, Meyer Raanan, Mohr-Sasson Aya, Volodarsky-Perel Alexander, Zilberman Itamar, Armon Shunit, Jakobson-Setton Ariella, Eitan Ram, Kadan Yfat, Beiner Mario, Josephy Dana, Brodsky Malka, Friedman Eitan, Anafi Liat, Molchanov Yossef, Korach Jacob, Geiger Tamar, Levanon Keren

Abstract excerpt

No current screening methods for high-grade ovarian cancer (HGOC) guarantee effective early detection for high-risk women such as germline BRCA mutation carriers. Therefore, the standard-of-care remains risk-reducing salpingo-oophorectomy (RRSO) around age 40. Proximal liquid biopsy is a promising source of biomarkers, but sensitivity has not yet qualified for clinical implementation. We aimed to develop a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Genes, BRCA2

Share to Germ-Line Mutation

Share to Ovarian Neoplasms

Share to Ovariectomy

Share to Proteomics

Share to Salpingo-oophorectomy

Source

Open in PubMed

Identifiers

PMID: 36214786
DOI: 10.1002/ijc.34318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteomic signature for detection of high-grade ovarian cancer in germline BRCA mutation carriers.PMID 36214786Read ↗

Proteomic landscape of epithelial ovarian cancer.Semantic proximity Read ↗

[Recommendations for biomarker testing in epithelial ovarian cancer. A national consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology].Semantic proximity Read ↗

Profiling extracellular vesicles in circulation enables the early detection of ovarian cancerSemantic proximity Read ↗

Deep plasma proteomics identifies and validates an eight-protein biomarker panel that separate benign from malignant tumors in ovarian cancerSemantic proximity Read ↗

Applications of Proteomics in Ovarian Cancer: Dawn of a New EraSemantic proximity Read ↗

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional statusSemantic proximity Read ↗

Early and accurate detection of ovarian cancer by profiling cell-free mitochondrial DNA fragmentomics in multi-ethnic populationSemantic proximity Read ↗

Preneoplastic Lesions Fimbria Early Diagnosis Markers Underlying Timeline Mechanisms at The Origin of Ovarian Cancer in BRAC1/2 Patients: Case Reports Based on Proteogenomic StudySemantic proximity Read ↗

Multi-analyte approach combining cfDNA sequencing and protein testing for early ovarian cancer detectionSemantic proximity Read ↗

Preneoplastic lesions fimbria pan-proteomic studies establish the fimbriectomy benefit for BRCA1/2 patients and identify early diagnosis markers of HGSCSemantic proximity Read ↗

The Application of Liquid Biopsy for the Development and Validation of a Non-Invasive Screening and Diagnosis Test for Endometrial Premalignant and Malignant Lesions: A Prospective Innovative Pilot StudySemantic proximity Read ↗

Machine Learning analysis of high-grade serous ovarian cancer proteomic dataset reveals novel candidate biomarkers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.