A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants.

doi:10.1016/j.stem.2022.09.008

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Article

A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants.

Cell stem cell - 6 Oct 2022

Han Yuling, Tan Lei, Zhou Ting, Yang Liuliu, Carrau Lucia, Lacko Lauretta A, Saeed Mohsan, Zhu Jiajun, Zhao Zeping, Nilsson-Payant Benjamin E, Lira Neto Filipe Tenorio, Cahir Clare, Giani Alice Maria, Chai Jin Chou, Li Yang, Dong Xue, Moroziewicz Dorota, Paull Daniel, Zhang Tuo, Koo Soyeon, Tan Christina, Danziger Ron, Ba Qian, Feng Lingling, Chen Zhengming, Zhong Aaron, Wise Gilbert J, Xiang Jenny Z, Wang Hui, Schwartz Robert E, tenOever Benjamin R, Noggle Scott A, Rice Charles M, Qi Qibin, Evans Todd, Chen Shuibing

Abstract excerpt

Population-based studies to identify disease-associated risk alleles typically require samples from a large number of individuals. Here, we report a human-induced pluripotent stem cell (hiPSC)-based screening strategy to link human genetics with viral infectivity. A genome-wide association study (GWAS) identified a cluster of single-nucleotide polymorphisms (SNPs) in a cis-regulatory region of the NDUFA4 gene,...

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Identifiers

PMID: 36206731
DOI: 10.1016/j.stem.2022.09.008
PMCID: PMC9550219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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