Neuropathology of central nervous system involvement in TTR amyloidosis.

Abstract excerpt

Hereditary transthyretin amyloidosis (ATTRv) is a systemic disease caused by the accumulation of misfolded transthyretin (TTR). It usually presents with an adult-onset progressive axonal peripheral neuropathy and cardiomyopathy. In the central nervous system (CNS), variant TTR is produced by the choroid plexus and accumulates in the leptomeninges. CNS symptoms have been increasingly recognized in this population,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid Neuropathies, Familial
• Share to Brain