Article
miR-181a/b downregulation: a mutation-independent therapeutic approach for inherited retinal diseases.
EMBO molecular medicine - 8 Nov 2022
Carrella Sabrina, Di Guida Martina, Brillante Simona, Piccolo Davide, Ciampi Ludovica, Guadagnino Irene, Garcia Piqueras Jorge, Pizzo Mariateresa, Marrocco Elena, Molinari Marta, Petrogiannakis Georgios, Barbato Sara, Ezhova Yulia, Auricchio Alberto, Franco Brunella, De Leonibus Elvira, Surace Enrico Maria, Indrieri Alessia, Banfi Sandro
Abstract excerpt
Inherited retinal diseases (IRDs) are a group of diseases whose common landmark is progressive photoreceptor loss. The development of gene-specific therapies for IRDs is hampered by their wide genetic heterogeneity. Mitochondrial dysfunction is proving to constitute one of the key pathogenic events in IRDs; hence, approaches that enhance mitochondrial activities have a promising therapeutic potential for these...
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