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Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia

15 Sept 2022

Abstract excerpt

Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia-gut microbiota-CYP450/drug transporter axis is emerging as a vital factor in drug metabolism. However, the mechanisms through which the gut microbiota mediates the regulation of CYP450/drug transporters under high-altitude hypoxia have not been well defined. In this study, we investigated the...

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PMID: 36188572
DOI: 10.3389/fphar.2022.977370

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