Characterising the bidirectional biomolecular interactions between the intestinal microbiota and host drug metabolism

Abstract excerpt

In pharmacological and toxicological studies, the aim is to improve drug efficacy while limiting toxicity. It is now recognised that the gut microbiota, which constitutes trillions of microbial cells and contains 150 time more genes that the human genome itself, can synthesise enzymes and metabolites that can influence the metabolism and toxicity of drugs in the host. Conversely, drugs themselves have also been id...

Topics

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• Berberine and alkaloids research
• Cannabis and Cannabinoid Research
• Clostridium difficile and Clostridium perfringens research
• Diet and metabolism studies
• Diet, Metabolism, and Disease
• Gut microbiota and health
• Metabolomics and Mass Spectrometry Studies
• Pharmacogenetics and Drug Metabolism

Identifiers and source

Literature Corpus work

93d94d52-814d-5616-abf2-9e1e0f61e1d6

DOI

10.25560/89730