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Article

Breakdown of the central synapses in C9orf72-linked ALS/FTD

16 Sept 2022

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease that leads to the death of motor and cortical neurons. The clinical manifestations of ALS are heterogenous, and efficacious treatments to significantly slow the progression of the disease are lacking. Cortical hyper-excitability is observed pre-symptomatically across disease-causative genetic variants, as well as in the early...

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PMID: 36187344
DOI: 10.3389/fnmol.2022.1005112

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