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Article

Genetic evaluation of HAND2 gene and its effects on thalidomide embryopathy.

Birth defects research - 1 Dec 2022

Rengel Bruna Duarte, Kowalski Thayne Woycinck, Bremm João Matheus, do Amaral Gomes Julia, Schüler-Faccini Lavínia, Vianna Fernanda Sales Luiz, Fraga Lucas Rosa

Abstract excerpt

BACKGROUND: HAND2 is a transcription factor important for embryonic development, required for limbs and cardiovascular development. Thalidomide is a drug responsible to a spectrum of congenital anomalies known as Thalidomide Embryopathy (TE), which includes mainly limb and heart defects. It is known that HAND2 interaction with TBX5, an important protein for limbs and heart development, is inhibited by...

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Identifiers

PMID: 36177858
DOI: 10.1002/bdr2.2092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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