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Article

A HAND to TBX5 Explains the Link Between Thalidomide and Cardiac Diseases.

Scientific reports - 3 May 2017

Khalil Athar, Tanos Rachel, El-Hachem Nehmé, Kurban Mazen, Bouvagnet Patrice, Bitar Fadi, Nemer Georges

Abstract excerpt

Congenital heart disease is the leading cause of death in the first year of life. Mutations only in few genes have been linked to some cases of CHD. Thalidomide was used by pregnant women for morning sickness but was removed from the market because it caused severe malformations including CHDs. We used both in silico docking software, and in vitro molecular and biochemical methods to document a novel interaction...

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Topics

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Share to T-Box Domain Proteins

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Source

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Identifiers

PMID: 28469241
DOI: 10.1038/s41598-017-01641-3
PMCID: PMC5431093

Genes

TBX5
HAND2
NPPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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