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Article

Prospective avenues for human population genomics and disease mapping in southern Africa.

Molecular genetics and genomics : MGG - 1 Sept 2020

Swart Yolandi, van Eeden Gerald, Sparks Anel, Uren Caitlin, Möller Marlo

Abstract excerpt

Population substructure within human populations is globally evident and a well-known confounding factor in many genetic studies. In contrast, admixture mapping exploits population stratification to detect genotype-phenotype correlations in admixed populations. Southern Africa has untapped potential for disease mapping of ancestry-specific disease risk alleles due to the distinct genetic diversity in its...

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PMID: 32440765
DOI: 10.1007/s00438-020-01684-8
PMCID: PMC7240165

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