Article
Building a tissue: Mesenchymal and epithelial cell spheroids mechanical properties at micro- and nanoscale.
Acta biomaterialia - 15 Jul 2023
Kosheleva Nastasia V, Efremov Yuri M, Koteneva Polina I, Ilina Inna V, Zurina Irina M, Bikmulina Polina Y, Shpichka Anastasia I, Timashev Peter S
Abstract excerpt
Cell transitions between the epithelial and mesenchymal phenotypes provide the regulated morphogenesis and regeneration throughout the ontogenesis. The tissue mechanics and mechanotransduction play an essential role in these processes. Cell spheroids reproduce the cell density of native tissues and represent simple building blocks for the tissue engineering purposes. The mechanical properties of mesenchymal and...
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