Article
Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients.
British journal of haematology - 1 May 2022
Swinkels Maurice, Atiq Ferdows, Bürgisser Petra E, van Moort Iris, Meijer Karina, Eikenboom Jeroen, Fijnvandraat Karin, van Galen Karin P M, de Meris Joke, Schols Saskia E M, van der Bom Johanna G, Cnossen Marjon H, Voorberg Jan, Leebeek Frank W G, Bierings Ruben, Jansen A J Gerard
Abstract excerpt
Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) or qualitative (type 2A/2B/2M/2N) defects of circulating von Willebrand factor (VWF). Circulating VWF levels not always fully explain bleeding phenotypes, suggesting a role for alternative factors, like platelets. Here, we investigated platelet factor 4 (PF4) in a large cohort of patients with VWD. PF4 levels were lower in...
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