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Article

Reduced-illuminance autofluorescence imaging in ABCA4-associated retinal degenerations.

Journal of the Optical Society of America. A, Optics, image science, and vision - 1 May 2007

Cideciyan Artur V, Swider Malgorzata, Aleman Tomas S, Roman Marisa I, Sumaroka Alexander, Schwartz Sharon B, Stone Edwin M, Jacobson Samuel G

Abstract excerpt

The health of the retinal pigment epithelium (RPE) can be estimated with autofluorescence (AF) imaging of lipofuscin, which accumulates as a byproduct of retinal exposure to light. Lipofuscin may be toxic to the RPE, and its toxicity may be enhanced by short-wavelength (SW) illumination. The high-intensity and SW excitation light used in conventional AF imaging could, at least in principle, increase the rate of...

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Share to ATP-Binding Cassette Transporters
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Image Enhancement

Share to Lipofuscin

Share to Microscopy, Fluorescence

Share to Reproducibility of Results

Share to Retinal Degeneration

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Source

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Identifiers

PMID: 17429493
DOI: 10.1364/josaa.24.001457
PMCID: PMC2579898

Genes

ABCA4
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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