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Article

Rosemary Extract-Induced Autophagy and Decrease in Accumulation of Collagen Type I in Osteogenesis Imperfecta Skin Fibroblasts.

International journal of molecular sciences - 7 Sept 2022

Sutkowska-Skolimowska Joanna, Brańska-Januszewska Justyna, Strawa Jakub W, Ostrowska Halina, Botor Malwina, Gawron Katarzyna, Galicka Anna

Abstract excerpt

Osteogenesis imperfecta (OI) is a heterogeneous connective tissue disease mainly caused by structural mutations in type I collagen. Mutant collagen accumulates intracellularly, causing cellular stress that has recently been shown to be phenotype-related. Therefore, the aim of the study was to search for potential drugs reducing collagen accumulation and improving OI fibroblast homeostasis. We found that rosemary...

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Source

Open in PubMed Open full text

Identifiers

PMID: 36142253
DOI: 10.3390/ijms231810341
PMCID: PMC9499644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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