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Myosins and MyomiR Network in Patients with Obstructive Hypertrophic Cardiomyopathy

3 Sept 2022

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. The molecular mechanisms determining HCM phenotypes are incompletely understood. Myocardial biopsies were obtained from a group of patients with obstructive HCM (n = 23) selected for surgical myectomy and from 9 unused donor hearts (controls). A subset of tissue-abundant myectomy samples from HCM (n = 10) and controls (n = 6) was...

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PMID: 36140281
DOI: 10.3390/biomedicines10092180

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