Genetic Dissection of Hypertrophic Cardiomyopathy with Myocardial RNA-Seq.

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is an inherited disorder of the myocardium, and pathogenic mutations in the sarcomere genes myosin heavy chain 7 (MYH7) and myosin-binding protein C (MYBPC3) explain 60%-70% of observed clinical cases. The heterogeneity of phenotypes observed in HCM patients, however, suggests that novel causative genes or genetic modifiers likely exist. Here, we systemically evaluated RNA-seq...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Myosins
• Share to Cardiomyopathy, Hypertrophic
• Share to Gene Ontology