Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function.

Scientific reports - 22 Sept 2022

Wood Aleksandar R, Foliaki Simote T, Groveman Bradley R, Walters Ryan O, Williams Katie, Yuan Jue, Zou Wen-Quan, Haigh Cathryn L

Abstract excerpt

Cardiomyopathy is a co-morbidity of some prion diseases including genetic disease caused by mutations within the PrP gene (PRNP). Although the cellular prion protein (PrP) has been shown to protect against cardiotoxicity caused by oxidative stress, it is unclear if the cardiomyopathy is directly linked to PrP dysfunction. We differentiated cardiomyocyte cultures from donor human induced pluripotent stem cells and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Creutzfeldt-Jakob Syndrome
Share to Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysine

Share to Mutation

Share to Myocytes, Cardiac

Share to Prion Proteins

Share to Superoxides

Source

Open in PubMed Open full text

Identifiers

PMID: 36138047
DOI: 10.1038/s41598-022-19631-5
PMCID: PMC9500067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function.PMID 36138047Read ↗

Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing.Semantic proximity Read ↗

Generation of a heterozygous TPM1-E192K knock-in human induced pluripotent stem cell line using CRISPR/Cas9 system.Semantic proximity Read ↗

Genomic Engineering of Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Semantic proximity Read ↗

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.Semantic proximity Read ↗

Generation of human iPSC line from an arrhythmogenic cardiomyopathy patient with a DSP protein-truncating variant.Semantic proximity Read ↗

Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A).Semantic proximity Read ↗

Human iPSC-Derived Cardiomyocytes from ALS Patients with C9ORF72 Mutation Exhibit Cellular Hallmarks of ALS PathologySemantic proximity Read ↗

Recent advances in animal and human pluripotent stem cell modeling of cardiac laminopathy.Semantic proximity Read ↗

Generation of an induced pluripotent stem cell line from the dermal fibroblasts of a patient with arrhythmogenic right ventricular cardiomyopathy carrying a PKP2/c.2489 + 1G > A mutation.Semantic proximity Read ↗

Generation of an RBM20-mutation-associated left-ventricular non-compaction cardiomyopathy iPSC line (UMGi255-A) into a DCM genetic background to investigate monogenetic cardiomyopathies.Semantic proximity Read ↗

CRISPR/Cas9-edited PKP2 knock-out (JMUi001-A-2) and DSG2 knock-out (JMUi001-A-3) iPSC lines as an isogenic human model system for arrhythmogenic cardiomyopathy (ACM).Semantic proximity Read ↗

Nanopatterned Human iPSC-Based Model of a Dystrophin-Null Cardiomyopathic PhenotypeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.