Article
GWAS of genetic factors affecting white blood cell morphological parameters in Sardinians uncovers influence of chromosome 11 innate immunity gene cluster on eosinophil morphology.
Human molecular genetics - 19 Feb 2023
Marongiu Michele, Pérez-Mejías Gonzalo, Orrù Valeria, Steri Maristella, Sidore Carlo, Díaz-Quintana Antonio, Mulas Antonella, Busonero Fabio, Maschio Andrea, Walter Klaudia, Tardaguila Manuel, Akbari Parsa, Soranzo Nicole, Fiorillo Edoardo, Gorospe Myriam, Schlessinger David, Díaz-Moreno Irene, Cucca Francesco, Zoledziewska Magdalena
Abstract excerpt
Few genome-wide association studies (GWAS) analyzing genetic regulation of morphological traits of white blood cells have been reported. We carried out a GWAS of 12 morphological traits in 869 individuals from the general population of Sardinia, Italy. These traits, included measures of cell volume, conductivity and light scatter in four white-cell populations (eosinophils, lymphocytes, monocytes, neutrophils)....
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