Twist alters the breast tumor microenvironment via choline kinase to facilitate an aggressive phenotype.

Abstract excerpt

Twist (TWIST1) is a gene required for cell fate specification in embryos and its expression in mammary epithelium can initiate tumorigenesis through the epithelial-mesenchymal transition. To identify downstream target genes of Twist in breast cancer, we performed microarray analysis on the transgenic breast cancer cell line, MCF-7/Twist. One of the targets identified was choline kinase whose upregulation resulted...

Topics

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• Cell Line, Tumor
• Choline
• Phenotype
• Phosphorylcholine
• Tumor Microenvironment