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Article

PIK3CA mutation status, progression and survival in advanced HR + /HER2- breast cancer: a meta-analysis of published clinical trials.

BMC cancer - 21 Sept 2022

Fillbrunn Mirko, Signorovitch James, André Fabrice, Wang Iris, Lorenzo Ines, Ridolfi Antonia, Park Jinhee, Dua Akanksha, Rugo Hope S

Abstract excerpt

BACKGROUND: Approximately 40% of hormone receptor positive/human epidermal receptor 2 negative (HR + /HER2-) metastatic breast cancer (mBC) patients harbor phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations. However, associations between PIK3CA mutation status and clinical outcomes among patients with HR + /HER2- mBC have been heterogeneous across clinical trials. This...

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Identifiers

PMID: 36131248
DOI: 10.1186/s12885-022-10078-5
PMCID: PMC9490901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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